Top 5 HIPAA-Compliant Servers for Healthcare Practices in 2025

In a healthcare environment, Protected Health Information (PHI) must be stored on systems that meet strict HIPAA compliance requirements. Choosing the right server is critical—not just for security and compliance, but also for performance, scalability, and cost-efficiency.

Whether you're a private dental office, a busy physical therapy clinic, or a multi-location medical practice, the right HIPAA-compliant server can streamline your operations while keeping your patients’ data safe.

At TidyView IT, we've compiled our list of the Top 5 HIPAA-Compliant Servers in 2025 that healthcare businesses can trust.

1. Dell PowerEdge T-Series (T350/T550)

A workhorse server built for small-to-medium medical practices. Dell's PowerEdge line offers robust physical security options and integrates seamlessly with most EHR systems.

Why It’s Great:

• Built-in encryption

• Optional RAID storage redundancy

• Ideal for on-premises EHR software

• Trusted vendor support

2. HPE ProLiant ML350 Gen11

Hewlett Packard Enterprise’s ProLiant line is popular in the healthcare industry for its scalability and strong remote management features.

Why It’s Great:

• Strong performance for growing practices

• Full disk encryption & TPM 2.0

• Integrated iLO for remote monitoring

• HIPAA-compliant deployment guides available

3. Lenovo ThinkSystem ST650 V3

Lenovo’s ThinkSystem series is ideal for practices that want speed, capacity, and reliable virtualization support.

Why It’s Great:

• AES encryption for PHI at rest

• Designed with healthcare compliance in mind

• Supports large volumes of simultaneous users

• Optional liquid cooling for quiet operation

4. Microsoft Azure Stack HCI

For practices going hybrid or fully virtual, Azure Stack HCI allows you to run cloud-connected servers with the control of on-prem infrastructure.

Why It’s Great:

• HIPAA and HITRUST certified

• Integrated cloud backup and redundancy

• Scalable across multiple locations

• Seamless Microsoft 365/Defender integration

5. TrueNAS Enterprise X-Series

Perfect for dental or chiropractic practices that need a high-capacity, affordable storage solution. TrueNAS is open-source, secure, and HIPAA-compliant with the right configuration.

Why It’s Great:

• Full-disk encryption and ZFS file system

• Redundant power, RAID support

• Excellent for practices storing imaging and X-rays

• Lower total cost of ownership

Server	Cost	Ease of Use (1–5)	Compatibility	Size (1–5)	Security
Dell PowerEdge T-Series	$$	4	Works with most EHRs	4	AES, Secure Boot
HPE ProLiant ML350 Gen11	$$$	3.5	Highly compatible	3	TPM 2.0, RAID, iLO
Lenovo ThinkSystem ST650 V3	$$$$	4.5	EHRs, virtualization	2	AES-256, BIOS lock
Azure Stack HCI	$$$	5	Microsoft ecosystem	5	Cloud HIPAA Certified
TrueNAS Enterprise X-Series	$	3	Storage-heavy environments	3	Encrypted ZFS, RAID

Final Thoughts

When selecting a server for your healthcare practice, always prioritize:

• Full disk encryption

• Redundancy (RAID or cloud backup)

• User access control

• Physical and remote security

The wrong choice can put patient data—and your reputation—at risk. Let TidyView IT help you select, configure, and manage the right HIPAA-compliant server for your practice’s needs.

Need help choosing the right server?📞 Call us at (817)873-9171 to schedule a consultation.